Comparison of the Mediterranean Diet and Other Therapeutic Strategies in Metabolic Syndrome: A Systematic Review and Meta-Analysis

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dc.contributor.authorBruna-Mejías, Alejandro
dc.date.accessioned2025-09-29T15:53:51Z
dc.date.available2025-09-29T15:53:51Z
dc.date.issued2025-06-19
dc.description.abstractThe Mediterranean diet (MD) is one of the healthiest diets, high in fiber, antioxidants, and unsaturated fats. MD improves lipid profiles, reduces inflammation, controls blood pressure, decreases insulin resistance, and enhances the sensitivity to this hormone, lowering the risks of Metabolic syndrome (MS). MS is characterized by central obesity, hypertension, insulin resistance, and dyslipidemia, increasing the risk of cardiovascular disease and type II diabetes. The objective of this study was to know the effectiveness of the MD versus other treatments in patients with MS. A systematic search across multiple databases, Medline, Embase, Web of Science, Scopus, Google Scholar, and Cinahl, was conducted using keywords such as “Mediterranean diet”, “Mediterranean food”, “eat mediterranean”, “Metabolic syndrome”, and “x syndrome”. A total of 12 studies met the inclusion criteria. Mediterranean diet at different doses versus other diets or other treatments showed significant improvements in clinical parameters, including BMI (mean difference of −0.83 95% CI: −0.93 to −0.74; p < 0.00001),waist circumference (mean difference = −1.81, CI = −2.63 to −0.99, p < 0.00001) triglycerides (mean difference = −22.38, CI = −32.86 to −11.90, p < 0.00001), Glucose (mean difference = −4.28, CI = −7.64 to −0.93, p = 0.005) and, HOMA IR (mean difference = −0.72, CI = −0.78 to −0.65, p < 0.00001), and Insulin resistance (mean difference = −2.98, CI = −3.27 to −2.69, p < 0.00001), all of which improved, Although there were more outcomes, these are the most important changes for patients with metabolic syndrome. MD improves metabolic and cardiovascular health, but study heterogeneity limits the results’ generalizability. Because of that, further research is needed to standardize approaches and explore their mechanisms. MD should be part of an optimized strategy that includes education and physical activity. The strength of the evidence was very low according to the GRADE approach. Further research is needed to support the efficacy of the Mediterranean diet in patients with MS.
dc.identifier.citationInternational Journal of Molecular Sciences, Vol. 26, N°12, 5887 (2025) p. 1-30.
dc.identifier.doihttps://doi.org/10.3390/ijms26125887
dc.identifier.issn1422-0067
dc.identifier.orcidhttps://orcid.org/0000-0002-1781-062X
dc.identifier.urihttps://hdl.handle.net/20.500.12254/4322
dc.language.isoeng
dc.publisherMDPI
dc.rightsAcceso abierto
dc.rights.licenseAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectMediterranean Diet
dc.subject.nabs07 - Protección y mejora de la salud humana
dc.subject.odsODS 3 - Salud y bienestar
dc.subject.oecd3.2.18 - Endocrinología y Metabolismo||3.3.4 - Nutrición, Dietética
dc.subject.techSD - Salud Digital
dc.titleComparison of the Mediterranean Diet and Other Therapeutic Strategies in Metabolic Syndrome: A Systematic Review and Meta-Analysis
dc.typeArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
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